New bacterial oxidases

The development of efficient expression systems for technically interesting enzymes, also known as oxidases, was subject of an R&D project under the overall control of the AC Biotec GmbH.

New bacterial oxidases
Chirale oxazolidinones are structural building blocks for innovative active agents
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This systematic work is the precondition to manage the use of oxidases for a multiplicity of environment-friendly production processes of important fine chemicals in a technical scale.
The processed oxidases are about a D-amino acid oxidase from the bacterium Arthrobacter, the L-amino acid oxidase from a Rhodococcus strain as well as the NADH-oxidase from a Lactobacillus brevis. These oxidases were produced, biochemically characterised and two of them even crystallised. Exemplary oxidase-catalysed applications were performed in a small scale and then received an online tracking with help of a specifically developed instrument, the RAMOS-technology.

Projektziel:
New bacterial oxidases
Projektträger:
AC Biotec GmbH Dr. Tibor Anderlei Prof.-Rehm-Straße 1 52428 Jülich
Telefon:
+49-2461-980119
Fax:
+49-2461-980450
URL:
www.acbiotec.com
E-Mail:
r.anderlei@acbiotec.com